Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin
نویسندگان
چکیده
منابع مشابه
Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin
Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti-related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus of the hypothalamus (ARC). However, there is a paucity of data about the poss...
متن کاملHypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.
Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is still incomplete. Here, we use pharmacological and genetic approaches to demonstrate that the physiological orexigenic response to ghrelin involves specific inhibition of fatty acid biosynthesis i...
متن کاملHypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin
Recent data suggest that ghrelin exerts its orexigenic action through regulation of hypothalamic AMP-activated protein kinase pathway, leading to a decline in malonyl-CoA levels and desinhibition of carnitine palmitoyltransferase 1A (CPT1A), which increases mitochondrial fatty acid oxidation and ultimately enhances the expression of the orexigenic neuropeptides agouti-related protein (AgRP) and...
متن کاملCCK inhibits the orexigenic effect of peripheral ghrelin.
CCK and ghrelin exert antagonistic effects on ingestive behavior. The aim of the present study was to investigate the interaction between ghrelin and CCK administered peripherally on food intake and neuronal activity in specific hypothalamic and brain stem nuclei, as assessed by c-Fos-like immunoreactivity (c-FLI) in nonfasted rats. Ghrelin (13 microg/kg body wt) injected intraperitoneally sign...
متن کاملPurification and mass spectrometric analysis of the κ opioid receptor
Kenneth M. Wannemacher, Alexandra Terskiy, Shengjie Bian, Prem N. Yadav, Hong Li, Richard D. Howells⁎ Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey-Graduate School of Biomedical Science, Newark, NJ, USA Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2013
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2013.28